Traditional drug development is a slow and costly process that leads to the production of new drugs.Virtual screening (VS) is a computational procedure that measures the similarity of molecules as one of its primary tasks.Many techniques for capturing the biological similarity between a test compound and a known target ligand have been established

Epidermal growth factor receptor (EGFR)-mutation-positive non-smallcell lung cancer (NSCLC) is incurable, despite high rates of response to EGFR tyrosine kinase inhibitors (TKIs).We investigated receptor tyrosine kinases (RTKs), Src family kinases and focal adhesion kinase (FAK) as genetic modifiers of innate resistance in EGFR-mutation-positive NS

Anthropogenic activities are exposing insects to elevated levels of toxic metals and are altering the bioavailability of essential metals.Metals and metal isotopes have also become promising tools for the geolocation of migratory insects.Understanding the pathways of metal incorporation in insect tissues is thus important for assessing the role of

The corona-generated space charge may vary in different air pressures, and the quantitative law between the corona-generated space charge density and air pressure has never been investigated.This work utilised computational approaches to explore the role of air pressure in the variation of negative corona-generated space charge.A negative fluid mod